Novel base material for pharmaceutical and/or cosmetic cream (herbal composition for itchy or infected skin)

ABSTRACT

The present invention relates to the preparation and use of compositions for the treatment of skin disorders itchy and/or infected skin such as impetigo, acne (on face, forehead scalp and on the back of the body) and fungal infection of skin and nails. Whether the infection may be acute or chronic or sub-acute or acute on chronic.  
     As well as for the promotion of non carrier state of the human beings and animals from some pathogenic bacteria such as staphylococci. The compositions are based on extracts from the plants  Cassia tora, Centratherum anthelminticum  and/or  Melia azadirachta . A variety of other herbal extracts may be included and the composition may take the form of a freeze dried or a spray dried powder or presence of this in a cream or ointment based on Ghee, or in a cream or ointment form developed with any other vehicle, or they may be in a powdered form without spray drying. That spray dried or freeze dried powder may be suspended in a suitable mouth wash or nasal drops. The herbs may be in a powdered form of suitable for preparing decoctions in hot water. Laboratory results are of Specimen Example 2. Specimen Example 1 I have found working on the patients clinically as broad spectrum covering pustules as well as fungal infections.

BACKGROUND OF THE INVENTION

This invention relates to the manufacture and use of herbal compositions for the treatment of various skin disorders itchy or infected skin such as impetigo, acne (on face, forehead scalp and on the back of the body) and fungal infection of skin and nails.

Acne

Acne is a disease of the pilosebaceous unit. It predominantly affects the face, back and chest. Perioral area of the face is more vulnerable. Still acne is not a simple face skin disorder, few patients with severe acne on the back or chest who have non on the face.

Acne is a mixture of, inflammation-infection process and favoured by the presence of time oriented hormonal imbalance.

Most commonly found anaerobes and/or aerobe-bacteria in the acne are Staphylococcus albus, Staphylococcus epidermidis, Pitirosporum ovale Propionaebacterium acnes.

One gentleman suffering from acne on his face and also on his back for years. He was reluctant for antibiotics because he knew that antibiotics gave more trouble. He came to me for natural treatment for keloids he was suffering for long time. I gave him oral compound and herbal cream to apply one month supply, on 25th day of treatment he came to me for cream supply. At that time I counted spots on his back out of 33 spots 25 spots were healed. I realised that this is Propionae bacterium has disappeared.

Now I would like to present a laboratory proof here.

Types of the Lesions

Comedones are of two types. Open (black heads), closed (whiteheads)

Open blackheads contain greyish greasy content of the pilosebaceous duct which is affected by acne process. Some blackheads develop into inflamed lesions.

Closed comedones (whiteheads) are caused by a distension of the pilosebaceous duct and these are more likely than open comedones (blackheads) to develop into inflamed lesions.

About a quarter of closed comedones spontaneously resolve within 3-4 days while the majority progress to become inflamed. Some whiteheads persist in a latent state for months.

Facial Scarring

Acne and Immune Response

As previously stated acne is a mixture of, inflammation- infection process and favoured by the presence of time oriented hormonal imbalance.

Pustules resolve faster than papules. In pustules natural healing process is faster because of polymorphonucleocyte activity and in papules the natural healing process is slower because here it depends on lymphocyte activity. Here this lymphocyte activity remains helpful in further growth of the comedones.

Macules are the end result of inflamed lesions, most persist for 7 days and they can linger for several weeks.

Present invention is useful for prevention of further scarring.

Facial Scarring

It is well recognised that facial scarring and scars on the back are associated with long standing changing guards-games played by different sorts of bacteria fungi and immune response of the body in the form of production and presentation of lymphocyte and polymorphonucleocytes.

Fungal Nail Infection and Immune Response

The skin in some people react to external and internal changes very fast such as drinking alcohol, washing with alkaline soap, increased sweating in summer and more humid skin environment. All these skin sensitising factors could bring circulatory changes on the skin and inside the nail beds.

It is well recognised that alkalinity on the skin initiates or promotes fungal infections. In long journey of antibiotics, resistance development and hide and seek games played by organisms the present invention remains most blissful.

The skin and blood purifier herbal composition for oral and topical treatments for Acne and fungal infections of skin and the nails

Oral Composition

Centratherum anthelminticum, Curcuma longa, Melia azardirachta, Picrorrhyza curroa, Cassia tora, Comiphora mukul, Withenia somnifera, Tinospora cordifolia, Asparagus racemosus, Triphala.

Topical Treatment

Centratherum anthelminticum, Melia azadirachta, Cassia tora.

Mouth Wash

Centratherum anthelminticum, Melia azadirachta, Cassia tora

Face Wash and Body Wash

Centratherum anthelminticum, Melia azadirachta, Cassia tora

Nasal Drops

Centratherum anthelminticum, Melia azadirachta, Cassia tora

SUMMARY OF THE INVENTION

According to a first aspect of the present invention, there is provided a composition for use in the treatment of skin disorders itchy or infected skin such as impetigo, acne (on face, forehead scalp and on the back of the body) and fungal infection of skin and nails, which composition comprises extracts derived from the seeds of the plant Centratherum anthelminthicum.

According to second aspect of the present invention, there is provided a composition for use in the treatment of skin disorders such as acne and/or fungal infection and/or fungal infections of the nails, which composition comprises extracts derived from the seeds of the plant Centratherum anthelminthicum fruit-oil and extract from leaves, bark, roots of the plant Melia azadirachta.

According to third aspect of the present invention, there is provided a composition for use in the treatment of skin disorders such as acne and/or fungal infection and/or fungal infections of the nails, which composition comprises extracts derived from the seeds of the plant Centratherum anthelininthicum fruit-oil and extract from leaves, bark, roots of the plant Melia azadirachta and extracts derived from the seeds of the plant Cassia tora.

According to fourth aspect of the present invention, there is provided a composition for use in the treatment of skin disorders such as acne and/or fungal infection and/or fungal infections of the nails, which composition comprises extracts derived from at least one member of the group consisting of the plants Centratherum anthelminticum, Melia azardirachta, Cassia tora which further comprises extracts derived from Picrorrhyza curroa, Comiphora mukul, Withenia somnifera, Tinospora cordifolia, Asparagus racemosus, Triphala.

According to fifth aspect of the present invention, there is provided a method of treating itchy skin or infected skin through the administration of extracts derived from at least one member of the group consisting of the plants Centratherum anthelminticum, Melia azadirachta, Cassia tora.

According to a sixth aspect of the present invention, there is provided a method of treating itchy and infected skin through the administration of extracts derived from at least one member of the group consisting of the plants Centratherum anthelminticum, Melia azadirachta, Cassia tora and further extracts derived from at least one member of the group consisting of the plants Picrorrhyza curroa, Comiphora mukul, Withenia somnifera, Tinospora cordifolia, Asparagus racemosus, Triphala.

According to a seventh aspect of the present invention, there is provided a method of treating infected skin through the administration of extracts derived from at least one member of the group consisting of the plants Centratherum anthelminticum, Melia azadirachta, Cassia tora.

According to an eighth aspect of the present invention, there is provided a method of treating acne and fungal infections of skin and the nails through the administration of extracts derived from at least one member of the group consisting of the plants Centratherum anthelminticum, Melia azadirachta, Cassia tora and further extracts derived from at least one member of the group consisting of the plants Picrorrhyza curroa, Comiphora mukul, Withenia somnifera, Tinospora cordifolia, Asparagus racemosus, Triphala.

The composition of the present invention may be dispersed in a suitable carrier for topical application as a cream, gel, ointment or lotion, or may be in the form of a dry powder, or other form suitable for a portable decoction, for example by way of a tea bag. Alternatively, the composition may be formulated in a tablet form, or composition may be formulated and made spray dried extract.

Preferably, the composition spray dried extract is dispersed in a carrier suitable for topical application comprising ghee, which is clarified butter.

The compositions of the present invention help to break the cycles of pruritus-inflamation-pruritus, and of infection-inflamation-pruritus, thereby promoting faster healing of acute, sub-acute and chronic bacterial and fungal infection of the skin and fungal of nails. The compositions of the present invention are additionally useful in reducing the effects of stress and reinforcing immune response.

Extracts from Centratherum anthelminticum, Melia azadirachta disperse in a sesame oil and cream was formulated with ghee and antimicrobial preservative efficacy test was performed using Propionibacterium acnes NCTC 737 was introduced in a cream Inoculum count cfu/ml 2.1×10 and significant results were seen logarithm reduction unto 5.32 was achieved at the 7 days inoculation test and 14 days inoculation tests.

(Extract from Cassia tora dispersed well with yogurt and heated and then applied on impetigo worked well. the activity was dose dependent.)

EXAMPLE 1

A preferred embodiment of the present invention is a cream made up as follows:

Ghee 3 kg

Water boiled and cooled freezing temperature 3 litres Freeze dried extract of Centratherum anthelminticum 5 gms (2 kilogram raw material of of the seeds provided 100 grams of freeze dried powder)

Medicated Sesame Oil 500 ml

(500 ml sesame oil treated with Centratherum anthelminticum seeds 100 gm, Rose petals 100 gm, Melia azadirachta leaves 100 gm, Cassia tora seeds 50 gm and some water to make a paste}.

To make up the cream, the ghee is first hydrolysed in a clean stainless steel vessel with three litres of water (boiled and cooled freezing ) then add 500 ml of medicated oil.

EXAMPLE 2

A preferred embodiment of the present invention is a cream made up as follows:

Ghee 3 kg

Water boiled and cooled freezing temperature 3 litres Freeze dried extract of Centratherum anthelminticum 5gms (2 kilogram raw material of of the seeds provided 100 grams of freeze dried powder)

Medicated Sesame Oil 500 ml

(500 ml sesame oil treated with Centratherum anthelminticum seeds 100 gm, Rose petals 100 gm, Melia azadirachta leaves 100 gm, and some water to make a paste).

To make up the cream, the ghee is first hydrolysed in a clean stainless steel vessel with three litres of water (boiled and cooled freezing) then add 500 ml of medicated oil. 

1. The use in the manufacture of a medicament for the treatment of impetigo, acne and fungal infections of the
 1. A method of making the cosmetic and/or Pharmaceutical cream comprising the following steps: a) First preparing an oil phase by adding Ghee, coconut oil, Cetyl alcohol, Laxemul, vegetable glycerine, and Neem kernel oil and sesame oil to a sterile vessel, heating said vessel to temperature of 98° C. and next cooling said vessel to a temperature 75° C.; b) Second, preparing a water phase by heating 65 litres of deionised water to 100° C. and next cooling said deionised water to a temperature 75° C.; c) Third, mixing said water phase with said oil phase; d) Forth, adding freeze dried water extracts of Cassia tora, Melia azadirachta, and Centratherum anthelminticum 5 mg, and dissolving said extracts to 485 millilitres of deionised water and adding 20 ml of rose oil to said freeze dried extracts.
 2. Method of making cream in claim 1 wherein 12 kg of Ghee, 5 kg cetyl alcohol 4 Kg, Laxemul, 1 kg vegetable Glycerine, and 0.500 kg of Neem kernel oil are used to manufacture said cream.
 3. Method of making cream in claim 1 wherein said cream has a pH of 5.5 to 6.5.
 4. Method of making cream in claim 1 where in and where in claim 2 the % of the minimum amount of Ghee would be 12%, below that level there would be failure of self protective mechanism of the cream against the fungus.
 5. Method of making cream in claim 1 where in by using Freeze dried extract of Cassia tora, Centratherum anthelminticum and Freeze dried extract of Melia azadirachta in CLAIM ONE where in the product treats skin disorders such as acne vulgaris and spots, infection due to Propionibacterium acnes and/or fungal infection and/or fungal infections of the nails and impetigo.
 6. Method of using Freeze dried extract of Centratherum anthelminticum and Freeze dried extract of Melia azadirachta in claim 1 where in the product treats eczema in children (age above 6 months), psoriasis, lichen planus and all sorts of itchy skin disorders.
 7. Method of using mixed oil-sesame oil treated with leaves of Melia azadirachta, seeds of Centratherum anthelminticum and rose petals in claim 1 where in the product treats skin disorders such as infantile eczema, achrodermatitis (those ladies on HRT treatment or on beta blockers are more vulnerable), very dry flaky, itchy seborrhoeic dermatitis.
 8. Method of making cream in claim 1 here in by using Freeze dried extract of Cassia tora, Centratherum anthelminticum and Freeze dried extract of Melia azadirachta where in claim 6 effectiveness of the product is compared with BENCHMARK OXY10 LOTION GLAXO SMITHKLINE, BATCH 213A CONTAINING 10% W/W BENZYL PEROXIDE.
 9. Method of making cream in claim 1 where in by using Freeze dried extract of Cassia tora, Centratherum anthelminticum and Freeze dried extract of Melia azadirachta where in claim 6 effectiveness of the product is seen clinically. 